Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines

Abstract Background Canine hemangiosarcoma (HSA) is a malignant tumor with poor long-term prognosis due to development of metastasis despite aggressive treatment.The phosphatidyl-inositol-3 kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is involved in its endothelial pathologies; however, it remains unknown how this pathway plays

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A comparison of contrast sensitivity in early mild and early intermediate age-related macular degeneration after adjusting for age and visual acuity

Background.It has been suggested that contrast sensitivity can provide valuable information about visual function in addition to visual acuity assessment.Some patients retain relatively good visual acuity, yet complain of poor vision.In these patients, other tests of visual function such as contrast sensitivity should be evaluated.Methods.We examin

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Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.

BackgroundBetaine (trimethylglycine) lowers plasma homocysteine, a possible risk factor for cardiovascular disease.However, studies in renal patients and in obese individuals who are on a weight-loss diet suggest that betaine supplementation raises blood cholesterol; data in healthy individuals are lacking.Such an effect on cholesterol would counte

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Role of STAT3 in pancreatic cancer

Pancreatic cancer remains a serious and deadly disease, impacting people globally.There remain prominent gaps in the current understanding of the disease, specifically regarding the role of the signal transducer and activator of transcription (STAT) family of proteins in pancreatic tumors.STAT proteins, particularly STAT3, play important Anti-persp

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